Project Discovery: Human Protein Atlas

What is Project Discovery

Project Discovery is a "citizen science", participation in scientific research by the lay community, project within EVE Online. A collaboration between CCP Games, Reyjavik University, the Human Protein Atlas, and Massively Multiplayer Online Science, it is used to characterize the structures of cells, using your identification skills, and will help scientists identify proteins within human cells. Because of this, playing Project Discovery helps scientists understands how human cells are built.
A brief tutorial and introduction to mechanics is present in the game.

In-game, the Sisters of EVE run Project Discovery for capsuleers to assist in identification of Drifter biological samples.

In addition to the above scientific participation and benefits, capsuleers also gain benefits within EVE Online. Each slide submitted results in a small amount of ISK - determined by your accuracy rating, with an accuracy of 50% conferring 50,000 ISK per slide, minus corporation tax - as well as Project Discovery-specific Analysis Kredits with the Sisters of EVE.

Basic Mechanics

Project Discovery can be accessed using your NeoCom, under the Business tab. Beginning to use it is as simple as pressing this button, then this button and following the tutorial.

Project Discovery icon

Its workflow consists of:

• Completing the Tutorial, if you haven't previously

• Presentation with a new slide
• Clicking on one or more cellular structure buttons, indicating you believe that the fluorescent green is identifying those structures
• Submitting the Image
• Feedback if enough other players have submitted the slide; if not, feedback won't be enabled yet

- It is at this step that, if consensus of players picks the same options, that your accuracy rating will be adjusted up or down based on which options you pick

• Rewards: ISK, Project Discovery Experience Points, and Sisters of EVE Analysis Kredits (not Loyalty Points)

- Reward quantities depend upon your accuracy rating

Completing the Tutorial

Before you start playing you will need to complete the tutorial. This teaches you the basic mechanics and what you should be looking for in the slides. You will start out from this page:

The tutorial will show you:

• How to zoom into the sample image
• How to fix the camera on a certain part of the image
• Where to find the categories
• How to filter the sample image to remove and re-add certain colours
• How to submit your analysis
• Where to find your rank and how to view your progress
• Where to find your accuracy rating
• How to view the tutorial again

You will then be shown ten slides on which a consensus has already been reached. These example slides are of varying difficulty, and you will need to select the category or categories you consider best match the sample slide.

Once you have completed the tutorial, you can start moving on to some other slides. Some of them will already have a consensus and some will not.

The layout of the page

Image	Description
	This is the sample image. You only need to categorise the green part. To the top left of the sample is a button to load a new sample.
	Directly below the sample image is the colour filter. You can use this to filter out certain colours to enable you to see the green more easily. You may find it useful to flick back and forth sometimes to see how the colours interact with each other.
	To the bottom left of the sample image (next to the colour filter) is a checkbox you can use to categorise a sample as 'abnormal'. You should do this when the image doesn't fit within any of the categories, or there is something wrong with the sample image itself.
	To the right of the sample image are all the possible categories you could select. You are free to select more than one category. If you hove over the categories you will be able to see a description of what each category is, together with several example images showing what this category looks like.
	At the bottom of the screen is the button to submit your analysis. Only press this when you have selected all the likely categories, as you cannot 'Undo' once it has been submitted.
	At the top of the window is your current rank. There is also a progress bar underneath which shows you how close you are to obtaining the next rank.
	Also at the top of the page is your current accuracy. This is based on the samples you have analysed which already have a general consensus. The greater your accuracy, they greater your rewards will be. This is an incentive to be careful when reviewing the samples, because if you get too many wrong your accuracy will start to suffer.
	Easy to overlook, in the very bottom left corner is the Help button, which enables you to do the tutorial again to re-familiarise yourself with the game.

What to Look For

The objective of Project Discovery slides is to identify what cellular structure(s) display a fluorescent green color. These can broadly be classified as within the nucleus, in the cell's cytoplasm, or even outside the cell in the periphery. If none of these are met, consider classifying the slide as not identifiable.

Categories

There are 29 distinct categories. Below is a summary of each and CCP's example image. You can also view three further examples of each by hovering over them in the Project Discovery window.

Category	Description	Image
Nucleus	Example	Example
Nucleoplasm	Example	Example
Nuclear bodies (few)	Example	Example
Nuclear bodies (many)	Example	Example
Nuclear speckles	Example	Example
Nucleoli	Example	Example
Nucleoli (rim)	Example	Example
Nucleoli (fibrillar center)	Example	Example
Nuclear membrane	Example	Example
Cytoplasm	Example	Example
Aggresome	Example	Example
Mitochondria	Example	Example
Rods and rings	Example	Example
Cytoskeleton (intermediate filaments)	Example	Example
Cytoskeleton (microtubule ends)	Example	Example
Cytoskeleton (microtubules)	Example	Example
Cytoskeleton (actin filaments)	Example	Example
Cytoskeleton (cytokinetic bridge)	Example	Example
Microtubule organizing center	Example	Example
Centrosome	Example	Example
Endoplasmic reticulum	Example	Example
The Golgi apparatus	Example	Example
Vesicles	Example	Example
Cell junctions	Example	Example
Focal adhesions	Example	Example
Plasma membrane	Example	Example
Cell-to-cell variations	Example	Example
Negative	Example	Example
Unspecific	Example	Example

Tips

• Most slides presented to players have 1-2 structures highlighted with fluorescent green, though it's possible that slides may have zero green structures or 3+ green structures.
  
• Cytoplasm, nucleus, and nucleolus seem to be the most frequent structures identifiable in this batch of images.
  
• Remember to focus on the fluorescent green color. Consider using the filters at the bottom of the image to hide red and/or blue to make identifying the green region easier.
  

This image demonstrates a capsuleer selected one element in the Nucleus and one element in the Cytoplasm; a majority of capsuleers agree with the cytoplasm structure choice - hence the green checkmark - but disagree with the nucleus structure choice - hence the red X.

What You Get Out of It

Upon submission of each slide, capsuleers are rewarded with ISK, Project Discovery experience, and Analysis Kredits.
The quantity of ISK and Project Discovery experience points are determined by the pilot's accuracy rating: at an accuracy rating of 50%, pilots will accumulate 50 EXP and 50,000 ISK per slide submitted.

Ranks are a method of quantifying the pilot's contribution to Project Discovery. Rank is increased by accumulating experience points.

Analysis Kredits may be spent at Sisters of EVE Loyalty Point stores, but they are not interchangeable with Loyalty Points. Instead, Analysis Kredits are used to purchase new Project Discovery -specific items including boosters and attire.

External Links

EVE Online: Project Discovery
Developer Blog Introducing Project Discovery
EVE Flight Academy Video by Professor Lundberg