The Blood-Stained Stars
Each epic mission arc is a special series of missions tied together in a dramatic story. These are often more difficult than standard missions of "equivalent" level, but have better narrative and often better rewards. The last mission in each arc gives a significant faction standing boost - with no derived standings changes to other factions - and may also award a valuable item. Each epic arc has at least one branch point where your decision of how to continue will affect both the story and your rewards.
The epic arcs can involve a lot of travel, but many of the missions can be accepted and/or completed remotely to reduce travel time. Epic arc missions do not expire, and each arc can be repeated every three months.
The Sisters of EVE epic arc, called "The Blood-Stained Stars", is a Level 1, 50-mission connected arc with a couple of choices in the middle and near the end that affect how the story will play out for you. This arc is definitely worth completing, as it provides some good experience for new pilots, along with some nice rewards and standings boosts. Most of these missions are easy to complete in a frigate with entry-level skills. However, a few can be quite challenging, and require some combat skill training and perhaps a larger ship, such as a destroyer or cruiser.
Note that mission rewards listed in this walkthrough are not affected by the Negotiation skill, but the standings gains (for various corporations during the arc, but mostly Sisters of EVE, and for the empire faction of your choice at the end) are affected by the Social skill. The arc does not give Loyalty Points.
Also, note that you sometimes can not interact with mission NPCs you meet floating in space if you are a member of a fleet (tested with the "Retribution" expansion). Only after dropping fleet will the option "start conversation with..." become available.
You will also receive an important storyline mission for every 16 missions (by type) you complete for the epic arc. These are optional but provide benefits if completed.
The epic arc contains missions with moderate combat and lots of traveling. The best ships for doing the arc are destroyers as they are have high firepower while also being fast. Common choices are Thrasher, Catalyst, Cormorant and Coercer.
The second last mission "Our Man Dagan" is especially notorous for hard to kill boss. you may want to bring modules with you to refit for higher dps for this mission.
Completing the missions gives money but no LP. The more lucrative reward is the faction standing boost you get from the final mission. +7% to empire faction of your choice with no derived standing changes (+8.75% with Social V). This is especially useful to those who have ruined their standing to below -2.00.